Piroxicam

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CAS Registry Number [36332-90-4] OH O

This nonsteroidal anti-inflammatory drug belongs to the oxicam class. It induces photo-allergic contact dermatitis rather than contact allergy. Systemic photosensitivity is frequent, in patients prev iously sensitized to thiomersal. Thiosalicylic acid, the nonmer-curial moiety of thiomersal, is a marker of photoallergy to piroxi-cam. Reactions are expected with piroxicam p-cyclodextrin but cross-sensitivity is generally not observed to tenoxicam or melox-icam (personal observations).

Suggested Reading

Arevalo A, Blancas R, Ancona A (1995) Occupational contact dermatitis from piroxicam. Am J Contact Dermat 6 : 113-114 De la Cuadra J, Pujol C, Aliaga A (1989) Clinical evidence of cross-sensitivity between thiosalicylic acid, a contact allergen, and piroxicam, a photoallergen. Contact Dermatitis 21:349-351

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