Auranofin

Trade name(s)

Ridaura

Generic available

Drug class

Anti-rheumatic

Mechanism of action

Inhibition of complement and lysosomal enzymes; normalization of defective Langerhans cell antigen presentation

Dosage form

3 mg tablet

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: skin eruption, stomatitis, pruritus, glossitis

Gastrointestinal: diarrhea, abdominal pain Laboratory: anemia, leukopenia, proteinu-ria

Neurologic: change in taste sensation Ocular: keratitis

Serious side effects

Bone marrow: agranulocytosis

Neurologic: seizures

Pulmonary: pneumonitis

Renal: renal failure, nephrotic syndrome

Drug interactions

Atovaquone/proguanil

Auranofin. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Cicatricial

S mg PO twice daily

Initial: 0.1 mg per kg daily in 1-2

pemphigoid

divided doses; usual maintenance:

0.15 mg/kg/day in 1-2 divided

doses; maximum: 0.2 mg/kg/day in

1-2 divided doses

Epidermolysis bullosa 3 mg PO twice daily acquisita

Initial: 0.1 mg per kg daily; usual maintenance: 0.15 mg/kg/day in 1-2 divided doses; maximum: 0.2 mg/kg/day in 1-2 divided doses

Epidermolysis bullosa 3 mg PO twice daily acquisita

Initial: 0.1 mg per kg daily; usual maintenance: 0.15 mg/kg/day in 1-2 divided doses; maximum: 0.2 mg/kg/day in 1-2 divided doses

Lupus erythematosus S mg PO twice daily

Initial: 0.1 mg per kg daily in 1-2 divided doses; usual maintenance: 0.15 mg/kg/day in 1-2 divided doses; maximum: 0.2 mg/kg/day in 1-2 divided doses

Pemphigus vulgaris 3 mg PO twice daily Initial: 0.1 mg per kg daily in 1-2

divided doses; usual maintenance: 0.15 mg/kg/day in 1-2 divided doses; maximum: 0.2 mg/kg/day in 1-2 divided doses

Aurothioglucose 73

Contraindications/precautions

Hypersensitivity to drug class or component; pulmonary fibrosis; bone marrow aplasia; caution with impaired liver or renal function

References

Papp KA, Shear NH (1991) Systemic gold therapy. Clinics in Dermatology 9(4):535-551

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