Aurothioglucose

Trade name(s)

Solganol

Generic available

Drug class

Anti-rheumatic

Mechanism of action

Inhibition of complement and lysosomal enzymes; normalization of defective Langerhans cell antigen presentation

Dosage form

Intramuscular injection

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: stomatitis, glossitis, skin eruption, pruritus

Gastrointestinal: diarrhea, abdominal pain, dyspepsia, change in taste sensation Laboratory: proteinuria, anemia, leukope-nia

Neurologic: change in taste sensation Ocular: keratitis

Serious side effects

Laboratory: agranulocytosis

Neurologic: seizures

Pulmonary: pneumonitis

Renal: renal failure, nephrotic syndrome

Drug interactions

Atovaquone/proguanil

74 Auspitz sign

Aurothioglucose. Dermatologic indications and dosage

Disease Adult dosage

Child dosage

Cicatricial 25-50 mg IM once weekly

Initial - 0.25 mg per kg per dose first

pemphigoid

week; increment at 0.25 mg per kg

per dose increasing with each

weekly dose; maintenance -

0.75-1 mg per kg per dose weekly,

not to exceed 25 mg per dose

Epidermolysis bullosa 25-50 mg IM once weekly

Initial - 0.25 mg per kg per dose first

acquisita

week; increment at 0.25 mg per kg

per dose increasing with each

weekly dose; maintenance -

0.75-1 mg per kg per dose weekly,

not to exceed 25 mg per dose

Lupus erythematosus; 25-50 mg IM once weekly

Initial - 0.25 mg per kg per dose first

pemphigus vulgaris;

week; increment at 0.25 mg per kg

cicatricial

per dose increasing with each

pemphigoid;

weekly dose; maintenance -

epidermolysis bullosa

0.75-1 mg per kg per dose weekly,

acquisita

not to exceed 25 mg per dose

Pemphigus vulgaris 25-50 mg IM once weekly

Initial - 0.25 mg per kg per dose first

week; increment at 0.25 mg per kg

per dose increasing with each

weekly dose; maintenance -

0.75-1 mg per kg per dose weekly,

not to exceed 25 mg per dose

Contraindications/precautions

References

Hypersensitivity to drug class or compo-

Bernhard JD (1997) Clinical pearl: auspitz sign in

nent; pulmonary fibrosis; bone marrow

psoriasis scale. Journal of the American Acade

aplasia; caution with impaired liver or renal

my of Dermatology 36(4):621

function

References

Autoeczematization

Papp KA, Shear NH (1991) Systemic gold therapy.

Clinics in Dermatology 9(4):535-55i

► Id reaction

Auspitz sign

Autoerythrocyte

Definition

sensitization

Bleeding points appearing when overlying

scale removed physically from a lesion of

► Autoerythrocyte sensitization syn-

psoriasis

drome

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