Autoimmune alopecia

► Alopecia areata

Azathioprine

Trade name(s)

Imuran

Azathioprine. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Atopic dermatitis

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Behget's disease Corticosteroid sparing function; Corticosteroid sparing function;

2-3 mg per kg PO daily 2-3 mg per kg PO daily

Behget's disease Corticosteroid sparing function; Corticosteroid sparing function;

2-3 mg per kg PO daily 2-3 mg per kg PO daily

Bullous pemphigoid Corticosteroid sparing function; Corticosteroid sparing function;

2-3 mg per kg PO daily 2-3 mg per kg PO daily

Bullous pemphigoid Corticosteroid sparing function; Corticosteroid sparing function;

2-3 mg per kg PO daily 2-3 mg per kg PO daily

Chronic actinic

Corticosteroid sparing function;

Corticosteroid sparing function;

dermatitis

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Cicatricial

Corticosteroid sparing function;

Corticosteroid sparing function;

pemphigoid

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Fogo selvagem

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Leukocytoclastic

Corticosteroid sparing function;

Corticosteroid sparing function;

vasculitis

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Lupus erythematosus,

Corticosteroid sparing function;

Corticosteroid sparing function;

acute

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Mixed connective

2-3 mg per kg PO daily

2-3 mg per kg PO daily

tissue disease

Paraneoplastic

Corticosteroid sparing function;

Corticosteroid sparing function;

pemphigus

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Pemphigus foliaceus

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Pemphigus vulgaris

Corticosteroid sparing function;

Corticosteroid sparing function;

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Persistent light

Corticosteroid sparing function;

Corticosteroid sparing function;

reaction

2-3 mg per kg PO daily

2-3 mg per kg PO daily

Polyarteritis nodosa Corticosteroid sparing function; Corticosteroid sparing function;

2-3 mg per kg PO daily 2-3 mg per kg PO daily

Polyarteritis nodosa Corticosteroid sparing function; Corticosteroid sparing function;

2-3 mg per kg PO daily 2-3 mg per kg PO daily

Corticosteroid sparing function; 2-3 mg per kg PO daily 2-3 mg per kg PO daily

Corticosteroid sparing function; 2-3 mg per kg PO daily 2-3 mg per kg PO daily

Pyoderma gangrenosum Relapsing polychondritis Sarcoidosis 2-3 mg per kg PO daily

Sulzberger-Garbe 2-3 mg per kg PO daily syndrome granulomatosis 2-3 mg per kg PO daily

Generic available

Drug class

Antimetabolite; immunosuppressant

2-3 mg per kg PO daily 2-3 mg per kg PO daily

2-3 mg per kg PO daily

Mechanism of action

Active metabolite is purine analog, which inhibits DNA and RNA synthesis and has immunosuppressive activity

Weber-Christian

2-3 mg per kg PO daily

2-3 mg per kg PO daily

disease

granulomatosis 2-3 mg per kg PO daily

2-3 mg per kg PO daily

Wegener's Corticosteroid sparing function; Corticosteroid sparing function;

Wegener's Corticosteroid sparing function; Corticosteroid sparing function;

Azelaic acid 77

Dosage form

50 mg tablet

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