Autoimmune dermatosis of pregnancy

Synonym(s)

Gardner-Diamond syndrome; autoerythrocyte sensitization; psychogenic purpura; purpura autoerythrocytica

Definition

Purpuric disorder in women, characterized by painful ecchymotic patches, unrelated to vascular or clotting abnormalities

Pathogenesis

Possibly an immune-mediated reaction; psychological issues in the patients possibly the main causative factor

Clinical manifestation

Painful ecchymoses, often appearing after minor trauma, usually over the extremities and trunk; lesions appearing in crops, and lasting for weeks to months

Differential diagnosis

Anaphylactoid purpura; Ehlers-Danlos syndrome; child abuse; factitial purpura; amy-loidosis; thrombotic thrombocytopenic purpura; solar purpura; leukemia

Therapy

Medroxyprogesterone acetate 10 mg PO per day or 150 mg intramuscularly once per month; prednisone; antihistamines, first generation

References

Berman DA, Roenigk HH, Green D (1992) Autoerythrocyte sensitization syndrome (psychogenic purpura). Journal of the American Academy of Dermatology 27(5 Pt 2^829-832

► Herpes gestationis

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