Azelaic acid

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: alopecia, skin eruption Gastrointestinal: nausea and vomiting, diarrhea, dyspepsia Laboratory: elevated liver enzymes

Serious side effects

Cutaneous: hypersensitivity reaction Gastrointestinal: hepatotoxicity, pancreatitis

Immune: immunosuppression Neoplastic: increased risk of neoplasm, particularly lymphoma

Trade name(s)

Azelex; Finacea

Generic available

Drug class

Anti-acne; anti-rosacea

Mechanism of action

May be related to antimicrobial effects

Dosage form

15% cream, 20% cream

Drug interactions

ACE inhibitors; allopurinol; cisplatin; cyto-toxic chemotherapeutic agents; interferon alfa 2a; interferon beta; mycophenolate mofetil; warfarin; zidovudine

Contraindications/precautions

Hypersensitivity to drug class or component; pregnancy; caution if patient has low levels or lacks thiopurine methyltrans-ferase (measure enzyme level before starting therapy); caution if impaired liver function

References

Silvis NG (2001) Antimetabolites and cytotoxic drugs. Dermatologic Clinics 19(1):105-118

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: pruritus, burning sensation, dryness, skin eruption

Serious side effects

None

Drug interactions

None

Contraindications/precautions

Hypersensitivity to drug class or component

Azelaic acid. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Acne vulgaris

Apply twice daily

Apply twice daily

Melasma

Apply twice daily

Apply twice daily

Postinflammatory

Apply twice daily

Apply twice daily

hyperpigmentation

Rosacea Apply twice daily Apply twice daily

Rosacea Apply twice daily Apply twice daily

78 Azithromycin

References

Nguyen QH, Bui TP (1995) Azelaic acid: pharma-cokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. International Journal of Dermatology 34(2)75-84

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