Azithromycin

Trade name(s)

Zithromax

Generic available

Drug class

Macrolide antibiotic

Mechanism of action

Inhibits protein synthesis of sensitive bacterial organisms

Dosage form

250 mg, 500 mg tablet; powder for oral suspension

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: skin eruption, vaginitis Gastrointestinal: nausea, vomiting, abdominal pain, diarrhea, anorexia

Serious side effects

Cutaneous: anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis Gastrointestinal: pseudomembranous colitis, cholestatic jaundice

Drug interactions

Antacids; oral contraceptives; warfarin; dig-oxin

Azithromycin. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Bacillary angiomatosis 500 mg PO on day 1; 250 mg PO on days 2-5

Not indicated in those < 45 kg in weight; 500 mg PO on day 1; 250 mg PO on days 2-5

Bartonellosis

500 mg PO on day 1; 250 mg PO on days 2-5

Not indicated in those < 45 kg in weight; 500 mg PO on day 1; 250 mg PO on days 2-5

Cellulitis

500 mg PO on day 1; 250 mg PO on days 2-5

Not indicated in those < 45 kg in weight; 500 mg PO on day 1; 250 mg PO on days 2-5

Chancroid

1 gm PO for 1 dose

Not indicated in those < 45 kg in weight; 20 mg per kg PO for 1 dose

Ecthyma

500 mg PO on day 1; 250 mg PO on days 2-5

Not indicated in those < 45 kg in weight; 500 mg PO on day 1; 250 mg PO on days 2-5

Furuncle

500 mg PO on day 1; 250 mg PO on days 2-5

Not indicated in those < 45 kg in weight; 500 mg PO on day 1; 250 mg PO on days 2-5

Impetigo

500 mg PO on day 1; 250 mg PO on days 2-5

Not indicated in those < 45 kg in weight; 500 mg PO on day 1; 250 mg PO on days 2-5

Trench fever 250-500 mg PO for 4 weeks Not indicated in those < 45 kg;

250 mg PO daily for 4 weeks

Trench fever 250-500 mg PO for 4 weeks Not indicated in those < 45 kg;

250 mg PO daily for 4 weeks

Azul 79

Azole antifungal agents. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Angular cheilitis

Apply twice da

ly for 2-4 weeks

Apply twice da

ly for 2-4 weeks

Cutaneous candidiasis

Apply twice da

ly for 2-4 weeks

Apply twice da

ly for 2-4 weeks

Majocchi granuloma

Apply twice da

ly for 4-8 weeks

Apply twice da

ly for 4-8 weeks

Onychomycosis

Apply twice da

ly for 2-4 weeks

Apply twice da

ly for 2-4 weeks

Tinea corporis

Apply twice da

ly for 2-4 weeks

Apply twice da

ly for 2-4 weeks

Tinea cruris

Apply twice dai

ly for 2-4 weeks

Apply twice dai

ly for 2-4 weeks

Tinea faciei

Apply twice dai

ly for 2-4 weeks

Apply twice dai

ly for 2-4 weeks

Tinea nigra

Apply twice dai

ly for 2-4 weeks

Apply twice dai

ly for 2-4 weeks

Tinea pedis

Apply twice dai

ly for 2-4 weeks

Apply twice dai

ly for 2-4 weeks

Tinea versicolor

Apply twice dai

ly for 2-4 weeks

Apply twice dai

ly for 2-4 weeks

White piedra

Apply twice dai

ly for 2-4 weeks

Apply twice dai

ly for 2-4 weeks

Contraindications/precautions

Hypersensitivity to drug class or component; caution in those with impaired liver function; do not use concomitantly with terfenadine or astemizole

References

Alvarez-Elcoro S, Enzler MJ (1999) The mac-rolides: erythromycin, clarithromycin, and azithromycin. Mayo Clinic Proceedings 74(6):6i3-634

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