Berloque dermatitis

Synonym(s)

Berlock dermatitis; perfume phototoxicity; bergapten phototoxicity; bergamot photo-toxicity; photodermatitis pigmentaria; dermite pigmentée en forme de coulée

Definition

Phototoxic reaction induced by the effect of long-wave ultraviolet (UVA) radiation on bergapten (5-methoxypsoralen), a photoactive component of bergamot oil

Pathogenesis

Photoactivation of bergapten by UVA radiation, causing phototoxicity and melanocyte stimulation to produce melanin; distribution of melanosomes in keratinocyte changing from the aggregate to disaggregated form, similar to that seen in skin of black individuals

► Berloque dermatitis

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