Blooms syndrome


Bloom syndrome; congenital telangiectatic erythema


Autosomal recessive disorder characterized by telangiectases and photosensitivity, growth deficiency, a variable degree of immunodeficiency, and increased susceptibility to neoplasms


Mutation in the gene designated BLM, on i5q26.i; protein encoded by the normal gene has DNA helicase activity and functions in the maintenance of genomic stability; mutation likely responsible for the phe-notype and the cancer predisposition

Clinical manifestation

Telangiectatic erythema in photodistrib-uted pattern; cheilitis; café au lait macules; bird-like facies; malar hypoplasia, small mandible; large, protruding ears; growth delay; short stature; malignancies, such as acute leukemia, lymphoma, and gastrointestinal adenocarcinoma

Differential diagnosis

Cockayne syndrome; Rothmund-Thomson syndrome; lupus erythematosus; erythro-poietic protoporphyria


No specific treatment; sun protection


German J (1995) Bloom's syndrome. Dermatolog-ic Clinics i3(i):7-i8

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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