Blue nevus

Synonym(s)

Nevus of Jadassohn and Tieche; blue neu-ronevus; dermal melanocytoma

Definition

Blue or blue-black skin lesion produced by a collection of functioning deep dermal melanocytes

Pathogenesis

Dermal arrest in fetal migration of melano-cytes of neural crest origin results in failure to reach the epidermis

Clinical manifestation

Smooth-surfaced, dome-shaped blue or blue-gray papules; common blue nevi less than 1 cm; cellular variant sometimes larger than 1 cm

Differential diagnosis

Melanoma; traumatic tattoo; seborrheic keratosis; dermatofibroma; nevus of Ota/ Ito; cherry hemangioma

Therapy

Diagnostic biopsy if melanoma seriously considered; simple excision for cosmetic

References

Schaffer JV, Bolognia JL (2000) The clinical spectrum of pigmented lesions. Clinics in Plastic Surgery 27(3)391-408

lesions most commonly affecting the gastrointestinal tract

Pathogenesis

Unknown

Clinical manifestation

Multiple, protuberant, dark blue, compressible nodules; large, cavernous lesions that may compress vital structures; irregular blue macules or patches; multiple gastrointestinal hemangiomas which may bleed, cause intussusception, volvulus, or bowel infarction; other extra-cutaneous sites, including skull, central nervous system, thyroid, parotid gland, eyes, oral cavity, lungs, pleura, pericardium, musculoskele-tal system, peritoneal cavity, mesentery, kidney, liver, spleen, penis, vulva, and bladder

Differential diagnosis

Arteriovenous malformation; Kaposi's sarcoma; Mafucci syndrome; Klippel-Trenau-nay-Weber syndrome

Therapy

Destruction by electrodesiccation and curettage, liquid nitrogen cryotherapy; surgical excision; CO2 laser vaporization

References

Moodley M, Ramdial P (1993) Blue rubber bleb nevus syndrome: case report and review of the literature. Pediatrics 92(1^160-162

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