Bowenoid papulosis

Synonym(s)

Viral keratoses; bowenoid papulosis of the penis; bowenoid papulosis of the genitalia

Definition

Human papillomavirus (HPV)-induced wart with histologic features of Bowen's disease

Pathogenesis

HPV type 16 most common causative agent; sometimes also occurring with viral types 18, 31, 32, 33, 34, 35, 39, 42, 48, 51, 52, 53, and 54

Clinical manifestation

Solitary or multiple, pigmented papules with a flat-to-velvety surface; lesions sometimes coalescing into plaques; occur most commonly on the penile shaft or the external genitalia of females

Differential diagnosis

Seborrheic keratosis; squamous cell carcinoma; melanocytic nevus; lichen planus

Therapy

Local excision; destruction by electrodesic-cation and curettage, cryosurgery, CO2 laser ablation; tretinoin; podofilox; 5-fluor-ouracil cream

References

Schwartz RA, Janniger CK (1991) Bowenoid papulosis. Journal of the American Academy of Dermatology 24(2 Pt 1)1261-264

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