Caf au lait macule

Synonym(s)

Café au lait spot; hypermelanotic macule

Café au lait macule. Tan-brown patch on the chest wall

Definition

Discrete, tan-brown macule with irregular margins

Pathogenesis

Possibly represents increased melanocyte size or increased melanosome production

Clinical manifestation

Asymptomatic, 2-20 mm discrete tan-brown macule or patch; occurring in patients with neurofibromatosis, McCune-Albright syndrome, Watson's syndrome, proteus syndrome, Bloom's syndrome, pie-baldism, and Fanconi's anemia

Differential diagnosis

Lentigo; seborrheic keratosis; nevocellular nevus; nevus spilus; multiple lentigines syndrome

Therapy

Q-switched Nd:YAG or Q-switched ruby laser ablation; hydroquinone

References

Landau M, Krafchik BR (1999) The diagnostic value of cafe-au-lait macules. Journal of the American Academy of Dermatology 40(6 Pt i):877-890

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