Centrofacial lentiginosis

► LEOPARD syndrome

Gastrointestinal: nausea, vomiting, diarrhea

Laboratory: eosinophilia, elevated liver enzymes

Neurologic: headache, dizziness


Trade name(s)

Keflex; Keftab; Biocef

Serious side effects

Bone marrow: thrombocytopenia, neutro-penia

Gastrointestinal: pseudomembranous colitis

Immunologic: anaphylaxis

Generic available

Drug class

Cephalosporin antibiotic Mechanism of action

Inhibition of penicillin-binding proteins, which results in defective bacterial cell wall synthesis

Dosage form

250 mg, 500 mg tablet; 125 mg per 5 ml, 250 mg per 5 ml suspension

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: skin eruption

Drug interactions

Aminoglycoside antibiotics; oral contraceptives; probenecid


Hypersensitivity to drug class or component; caution if there is a history of penicillin allergy; caution with impaired renal function or if patient is lactating


Sadick N (2001) Systemic antibiotics. Dermato-logic Clinics 19(1):1-24>

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