Soft chancre


Sexually transmitted genital disease, caused by the gram-negative bacillus Haemophilus ducreyi, characterized by painful genital ulcers and inflammatory inguinal adenopa-thy


Caused by gram-negative bacillus Haemo-philus ducreyi; organism produces a potent distending toxin, probably contributing to the production and slow healing of ulcers

Clinical manifestation

Disease in men: painful, erythematous papules at the site of recent sexual contact; foreskin most common site of infection, but occasionally occurring on the shaft, glans, or meatus of the penis; lesions become pustular and then ulcerate; associated with regional lymphadenopathy; constitutional symptoms, such as malaise and low-grade fevers

Disease in women: ulcers most commonly occur on the labia majora but sometimes also on the labia minora, thigh, perineum, or cervix; lesions usually less symptomatic than in men

Differential diagnosis

Syphilis; lymphogranuloma venereum; herpes simplex virus infection; traumatic ulceration; aphthae; Behcet's disease; Crohn's disease; fixed drug reaction


Azithromycin; ciprofloxacin; 250 mg IM for 1 dose ceftriaxone

124 Charbon


Brown TJ, Yen-Moore A, Tyring SK (1999) An overview of sexually transmitted diseases. Part I. Journal of the American Academy of Dermatology 41(4)1511-532

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