Clinical manifestation

Primary stage: small, painless papule or herpetiform ulcer, usually on glans penis or vaginal wall, which heals within a few days; unilateral painful inguinal lymphadenopa-thy; horizontal group of inguinal nodes most commonly involved; enlargement of the nodes above and below the inguinal ligament (groove sign)

Tertiary stage: proctocolitis; perirectal abscess; fistulas; anal strictures; hyperpla-sia of intestinal and perirectal lymphatics; end result sometimes elephantiasis of the female genitalia, characterized by fibrotic labial thickening, or elephantiasis and deformation of the penis in men

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