Clinical manifestation

Unifocal disease (eosinophilic granuloma): solitary bony lesion, usually asymptomatic Multifocal disease (Hand-Schuler-Christian variant): diabetes insipidus; bony defects; exophthalmos; other features: liver, spleen, lymph node infiltration; skin lesions, including noduloulcerative lesions in the oral, perineal, perivulvar, or retroau-ricular regions

Acute disseminated disease (Letterer-Siwe): skin findings, including petechiae; scaly or crusted yellow-brown papules, sometimes coalescing to form plaques, often in sebor-rheic distribution; exudative intertriginous lesions sometimes ulcerating; fever; anemia; thrombocytopenia; pulmonary infiltrates; lymphadenopathy; hepatosplenome-galy; neurologic involvement

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