Clinical manifestation

Primary stage: incubation period of 9-90 days; primary lesion (mother yaw) at site of inoculation after a scratch, bite, or abrasion, most commonly on legs, feet, or buttocks; nontender, occasionally pruritic, red papule or nodule that ulcerates; satellite lesions may coalesce to form plaque; lym-phadenopathy; fever; joint pain; mother yaw resolves spontaneously in 2-9 months, leaving atrophic scar with central hypopig-mentation

Secondary stage: beginning 6-16 weeks after primary stage, skin lesions (daughter yaws) resembling mother yaw but smaller; periorificial location; lesions expand, ulcerate, and exude a fibrinous fluid that dries into a crust; red, scaly papules and plaques that resemble syphilis over any part of the body; moist lesions in axillae, groin, mucous membranes; papillomas on plantar surfaces; macules or hyperkeratotic papules on palms and soles; skeletal involvement: painful osteoperiostitis; fusiform soft tissue swelling of the metatarsals and meta-carpals; may develop relapses after healing up to 5 years following infection Late stage: occurs after 5-15 years of latency; progressively enlarging, painless, subcutaneous nodules that ulcerate, with well-defined edges and indurated base with granulation tissue and yellowish slough; keratoderma of palms and soles; juxtaartic-ular ulcerated gummatous nodules; skeletal lesions consisting of hypertrophic periostitis, gummatous periostitis, osteitis, and osteomyelitis

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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