Clinical manifestation

Group 1 subtype: precedes febrile illness, particularly upper respiratory tract strepto-coccal infection; usually clears in 6 months to 2 years

Group 2 subtype: no prior history of febrile illness; insidious onset of skin lesions; at risk of developing paraproteinemias, including multiple myeloma Group 3 subtype: prior history of diabetes mellitus, usually adult onset and insulin dependent, unremitting course; ill-defined, woody, nonpitting, indurated plaques; erythema, hyperpigmentation, and/or a peau d'orange appearance; usually located on face, neck, trunk, or upper extremities

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