Clinical manifestation

Presenting symptom in all types: excessive fatigue associated with a hypochromic anemia and splenomegaly Type i (adult nonneuronopathic form): onset of the manifestations from early childhood to late adulthood; generalized yellowish bronze hyperpigmentation; bleeding, secondary to thrombocytopenia, manifested as epistaxis and ecchymoses; sequlae of monoclonal gammopathy or multiple myeloma

Type 2 (infantile or acute neuronopathic type): collodion-type skin changes or ich-thyosis; hepatosplenomegaly; rapid neurologic deterioration, leading to death within the first year of life

Type 3 (juvenile, Norrbotten, or subacute neuronopathic form): neurologic signs such as deficits in eye movements, cerebellar abnormalities, tonic-clonic seizures, or myoclonus; hypersplenism and skeletal changes similar to those in the chronic non-neuronopathic form

► Berardinelli-Seip syndrome

Genetic hemochromatosis

► Hemochromatosis

Genital wart

► Condyloma acuminatum

Geographic tongue

► Benign migratory glossitis

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