Clinical manifestation

Silvery blond hair; occasional subtle pigmentary dilution of the skin and iris and hyperpigmentation in sun-exposed areas; accelerated phase of the disease with fever, jaundice, hepatosplenomegaly, lymphaden-opathy, pancytopenia and generalized lym-phohistiocytic infiltrates of various organs including the central nervous system; neurologic manifestations: hyperreflexia, seizures, signs of intracranial hypertension, regression of developmental milestones,

Griseofulvin 267

Griseofulvin. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Onychomycosis

500 mg PO twice daily for

5-10 mg per kg PO daily for

6-12 months

6-12 months

Tinea capitis 250-500 mg PO twice daily for 25 mg per kg PO daily for 6-8 weeks

6-8 weeks

Tinea capitis 250-500 mg PO twice daily for 25 mg per kg PO daily for 6-8 weeks

6-8 weeks

Tinea corporis

250-500 mg PO twice daily for

5-10 mg per kg PO daily for

2-6 weeks

2-4 weeks

Tinea cruris Tinea faciei

250-500 mg PO twice daily for 2-6 weeks

250-500 mg PO twice daily for 2-6 weeks

5-10 mg per kg PO daily for 2-4 weeks

25 mg per kg PO daily for 6-8 weeks

Tinea cruris Tinea faciei

250-500 mg PO twice daily for 2-6 weeks

250-500 mg PO twice daily for 2-6 weeks

5-10 mg per kg PO daily for 2-4 weeks

25 mg per kg PO daily for 6-8 weeks

hypertonia, nystagmus, and ataxia; variety of immunological abnormalities, restricted to the patients with RAB27A defect

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