Clinical manifestation

Skin changes: facial plethora; striae; ecchymoses and purpura; telangiectasias; skin atrophy; hirsutism and male pattern balding in women; increased lanugo facial hair; steroid acne; acanthosis nigricans Central obesity; increased adipose tissue in the face (moon facies), upper back at the base of neck (buffalo hump), and above the clavicles

Endocrine abnormalities: hypothyroidism; galactorrhea; polyuria and nocturia from diabetes insipidus

Menstrual irregularities, amenorrhea, and infertility

Other organ system abnormalities: cardiovascular; musculoskeletal; gastroentero-logic; neuropsychological

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