Clinical manifestation

Usually starts with pulmonary infection followed by cutaneous, osseous, genitourinary, or central nervous system involvement; skin findings: most common manifestation of extrapulmonary disease; lesions favor exposed areas; minimally tender papules or pustules evolve into purulent, verrucous, or ulcerative nodules or plaques, characterized by sharp and heaped-up borders with centrally located granulation tissue and exudate; pulmonary findings: signs of acute pneumonia, including fever, night sweats, wheezing and dyspnea; signs and symptoms of chronic pneumonia last for 26 months, including weight loss, night sweats, fever, cough, and chest pain; osteo-lytic bone lesions; prostatitis or epididymi-tis

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