Clinical manifestation

Infantile myofibromatosis: one or multiple, rubbery or hard, skin-colored papules, either superficial or deep to the muscle, most commonly occurring on the head, neck, and trunk; usually present at birth or within the first few months of life; regression by age 2 years; viscera rarely involved, but if so, prognosis is poor Fibrous hamartoma of infancy: usually present at birth, often in the axillary area, shoulder or groin region; presents as enlarging subcutaneous nodule; occasional spontaneous resolution Juvenile hyaline fibromatosis (systemic hyalinosis): onset in early infancy with multiple, hard or soft, fixed or mobile, translucent papules and nodules of the scalp, face,

Juvenile xanthoma 319

gingivae, neck and trunk; osteolytic lesions of skull, long bones, or phalanges; poor muscle development; joint contractures in adult life

Infantile digital fibromatosis: multiple, firm, smooth, pink or flesh-colored papules of the fingers or toes, at birth or early childhood, often with spontaneous regression after 2-3 years

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