Clinical manifestation

NF-i variant: 6 or more café au lait macules larger than 0.5 cm in prepubertal individuals and those larger than 1.5 cm in postpu-bertal individuals; two or more neurofibro-mas of any type or 1 plexiform neurofi-broma; axillary freckling; optic glioma; iris hamartomas (Lisch nodules); osseous lesions

NF-2 variant: 8th cranial nerve tumors; neu-rofibromas; meningiomas; gliomas; schwannomas

Segmental variant: multiple soft papules (neurofibromas) in a nerve segment distribution

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