Clinical manifestation

Onset at birth or in neonatal period; adherent brown scaling in widespread distribution produces dirty-appearing skin; scaling of scalp, preauricular skin, and posterior neck; flexures sometimes involved, but palms and soles usually spared; scaling becomes more evident and assumes a dirty-yellow or brown color with dark, polygonal, firmly adherent scale; tends to fade on head but more prominent on trunk and extremities, particularly on the extensor surfaces of the legs; asymptomatic corneal opacities; occasional cryptorchidism

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