Clinical manifestation

Localized pain in an extremity, rapidly progressing over 48-72 hours Cutaneous signs: localized edema and erythema; bullous and hemorrhagic cellulitis; necrotizing fasciitis or myositis; gangrene Other organ involvement: fever; hypotension; cardiomyopathy; nausea; vomiting; diarrhea; rhabdomyolysis; myalgias; muscle tenderness and weakness; azotemia; acute renal failure; adult respiratory distress syndrome; elevated serum glutamic oxaloacetic transaminase (SGOT) and serum bilirubin; thrombocytopenia; leuko-cytosis; disseminated intravascular coagulation; hypophosphatemia; hypocalcemia; and electrolyte imbalance

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