Clinical manifestation

Variant caused by Streptobacillus moniliformis: fever, chills, headache, and muscle pain, usually occurring within 10 days of exposure, followed within 3 days by diffuse erythematous eruption, primarily in the distal extremities; ulceration at site of bite; one or several large joints sometimes become swollen, red, and painful; occasional splenomegaly

Variant caused by Spirillum minus (Sodoku): red or purple plaques; previously healed wound at site of bite sometimes reactivate and ulcerate; rare joint involvement

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