Common side effects

Cutaneous: hypertrichosis, acne, gingival hyperplasia

Gastrointestinal: nausea and vomiting, diarrhea, abdominal pain Laboratory: elevated liver function tests, elevated BUN and creatinine, hyperkale-mia, hyperuricemia, hypomagnesemia hyperglycemia

Cyclophosphamide. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Acute febrile

50-200 mg PO daily

Not indicated

neutrophilic dermatosis

Behcet's disease

50-200 mg PO daily

Not indicated

Bullous pemphigoid

50-200 mg PO daily

Not indicated

Cicatricial

50-200 mg PO daily

Not indicated

pemphigoid

Cryoglobulinemia

50-200 mg PO daily

Not indicated

Dermatomyositis

50-200 mg PO daily

Not indicated

Epidermolysis bullosa

50-200 mg PO daily

Not indicated

acquisita

Fogo selvagem

50-200 mg PO daily

Not indicated

Lichen

50-200 mg PO daily

Not indicated

myxedematosus

Lupus erythematosus

50-200 mg PO daily

Not indicated

Mixed connective

50-200 mg PO daily

Not indicated

tissue disease

Paraneoplastic

50-200 mg PO daily

Not indicated

pemphigus

Pemphigus foliaceus

50-200 mg PO daily

Not indicated

Pemphigus vulgaris

50-200 mg PO daily

Not indicated

Polyarteritis nodosa

50-200 mg PO daily

Not indicated

Pyoderma

50-200 mg PO daily

Not indicated

gangrenosum

Relapsing

50-200 mg PO daily

Not indicated

polychondritis

Scleroderma

50-200 mg PO daily

Not indicated

Vasculitis

50-200 mg PO daily

Not indicated

Weber-Christian

50-200 mg PO daily

Not indicated

disease

Wegener's granulomatosis

2 mg per kg PO daily or 0.5 g per m2 Not indicated IV every month for 6 months

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