Diphtheria cutaneous




Acute, toxin-mediated disease caused by Corynebacterium diphtheriae


C. diphtheriae (causative organism) an aerobic, toxin-producing, gram-positive bacillus; toxin production only when the bacillus infected by a specific virus carrying the genetic information for the toxin; only toxi-genic strains cause severe disease; toxin inhibiting cellular protein synthesis responsible for local tissue destruction and membrane formation; toxin produced at the site of the membrane absorbed into the bloodstream and disseminated

Clinical manifestation

Skin findings: seen mainly in homeless persons; erythematous scaling plaques; ulcers with an overlying membrane and demarcated edges; mucous membranes sometimes involved

Differential diagnosis

Other bacterial pyodermas; erythema multiforme; tropical ulcer; pyoderma gan-grenosum; Majocchi's granuloma; atypical mycobacterial infection; nocardiosis; aspergillosis; syphilis; granuloma inguinale; chancroid


Erythromycin; procaine penicillin G; diphtheria antitoxin 20,000-50,000 units IM*


Efstratiou A, Roure C (2000) The European Laboratory Working Group on diphtheria: A global microbiologic network. Journal of Infectious Diseases 181 Suppl 1:S146-151

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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