Drug class

Lincosamide antibiotic Mechanism of action

Binds to bacterial 50S ribosomal subunit, interfering with protein synthesis

Clindamycin, systemic. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Acne vulgaris

150 mg PO 2-3 times daily

Not indicated

Gas gangrene

15 mg per kg IV daily divided into

10 mg per kg daily IV divided into

3 doses

3 doses

Necrotizing fasciitis

600-900 mg IV every 6-12 hours

25-40 mg per kg IV divided into

3-4 doses daily

Paronychia, acute 150 mg PO 3 times daily for Not indicated

7-10 days

Streptococcal toxic 600-900 mg IV every 6-12 hours shock-like syndrome

25-40 mg per kg IV divided into 3-4 doses daily

Paronychia, acute 150 mg PO 3 times daily for Not indicated

7-10 days

Streptococcal toxic 600-900 mg IV every 6-12 hours shock-like syndrome

25-40 mg per kg IV divided into 3-4 doses daily

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