Drug interactions

Doxycycline; fluoroquinolones; carbamaze-pine; phenytoin

384 Methoxsalen

Methotrexate. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Bullous pemphigoid

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Chronic graft versus host disease

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Dermatomyositis

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Epidermolysis bullosa acquisita

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Lupus erythematosus

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Lymphomatoid papulosis

5-7.5 mg PO as a single weekly dose

2.5-5 mg PO as a single weekly dose

Mycosis fungoides

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Pemphigus vulgaris

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Pityriasis lichenoides

5-7.5 mg PO as a single weekly dose

2.5-5 mg PO as a single weekly dose

Pityriasis rubra pilaris

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Progressive systemic sclerosis

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Psoriasis

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Pyoderma gangrenosum

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Reiter syndrome

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Relapsing polychondritis

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Sarcoidosis

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Sézary syndrome

7.5-25 mg PO as a single dose weekly

5-15 mg PO as a single weekly dose

Vasculitis, including 7.5-25 mg PO as a single dose 5-15 mg PO as a single weekly dose polyarteritis nodosa weekly

Metronidazole, topical 385

Methoxsalen. Dermatologic indications and dosage

Disease

Adult dose

Child dose

Component of photochemotherapy - psoriasis; Reiter syndrome; cutaneous T cell lymphoma (mycosis fungoides; Sezary syndrome; vitiligo;

polymorphous light eruption; solar urticaria; chronic actinic dermatitis; morphea; linear scleroderma; graft versus host disease; lymphomatoid papulosis

Systemic photochemotherapy -0.4-0.6 mg per kg PO 1.5 hours before exposure to ultraviolet A light, either via light box, outdoor sunlight, or photopheresis; topical therapy - 0.1% lotion applied 30 minutes before exposure to ultraviolet A light

Systemic photochemotherapy -0.4-0.6 mg per kg PO 1.5 hours before exposure to ultraviolet A light, either via light box, outdoor sunlight, or photopheresis; topical therapy - 0.1% lotion applied 30 minutes before exposure to ultraviolet A light

Component of photopheresis - T-cell lymphoma (mycosis fungoides; Sézary syndrome)

0.4-0.6 mg per kg PO 1.5 hours before exposure to ultraviolet A light

0.4-0.6 mg per kg PO 1.5 hours before exposure to ultraviolet A light

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