Eosinophilic pustular folliculitis

Synonym(s)

Ofuji's disease; Ofuji disease; eosinophilic folliculitis; HIV-associated eosinophilic fol liculitis; HIV-related eosinophilic folliculitis, sterile eosinophilic pustulosis; eosinophilic pustular dermatosis; infantile/ childhood eosinophilic pustulosis of the scalp

Definition

Recurrent follicular and non-follicular papules associated with tissue and peripheral eosinophilia

Pathogenesis

Unclear; possibly abnormal immunologic reaction to follicular pathogens

Clinical manifestation

Follicular-based erythematous papules and pustules, with or without coalescence into plaques; face, back, and extensor surfaces of the upper extremities most commonly involved in adults; scalp most common site in children; increased incidence in HIV-infected patients; peripheral eosinophilia often present

Differential diagnosis

Other forms of folliculitis, including bacterial and fungal varieties; pustular psoriasis; acne; rosacea; perioral dermatitis; scabies; candidiasis; folliculitis decalvans; insect bite reaction; Langerhans cell histiocytosis; follicular mucinosis; superficial pemphigus

Therapy

Dapsone; super potent topical corticoster-oids; prednisone; isotretinoin; itracona-zole; UVB phototherapy; photochemother-apy

References

Lazarov A, Wolach B, Cordoba M, Abraham D, Vardy D (1996) Eosinophilic pustular folliculitis (Ofuji disease) in a child. Cutis 58(2)1135-138

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