Erythromycin topical

Trade name(s)

Emgel; Erycette; EryDerm; Erymax; Erythra-Derm; T-Stat; Theramycin; Staticin

Generic available

Drug class

Topical macrolide antibiotic; anti-inflammatory

Mechanism of action

Inhibition of RNA-dependent protein synthesis by binding to the 50S subunit of the ribosome

Dosage form

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: burning sensation, dryness, peeling, pruritus, erythema

Serious side effects

None

Drug interactions

Topical clindamycin

Erythromycin, topical 227

Erythromycin, systemic. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Acne vulgaris

250-1000 mg PO daily

250-500 mg PO daily

Acute necrotizing gingivitis

500 mg PO 4 times daily for 10 days

30-50 mg per kg daily divided into 4 doses for 10 days

Bacillary angiomatosis

500 mg PO 4 times daily for 3 weeks

30-50 mg per kg daily divided into 4 doses for 4 weeks

Bartonellosis

500 mg PO 4 times daily for 3 weeks

30-50 mg per kg daily divided into 4 doses for 10 days

Bejel

500 mg PO 4 times daily for 15 days

8 mg per kg daily divided into 4 doses for 15 days

Ecthyma

250-500 mg PO 4 times daily for 10 days

30-50 mg per kg daily divided into 4 doses for 10 days

Erythrasma

500 mg PO 4 times daily for 7-10 days

30-50 mg per kg daily divided into 4 doses for 7-10 days

Hidradenitis suppurativa

500 mg PO twice daily

30-50 mg per kg daily divided into 2 doses

Impetigo

250-500 mg PO 4 times daily for 10 days

30-50 mg per kg daily divided into 4 doses for 10 days

Leptospirosis

250-500 mg PO 4 times daily for 3 weeks

30-50 mg per kg daily divided into 4 doses for 3 weeks

Lyme disease

500 mg PO 4 times daily for 3 weeks

30-50 mg per kg daily divided into 4 doses for 10 days

Lymphogranuloma venereum

500 mg PO 4 times daily for 3 weeks

30-50 mg per kg daily divided into 4 doses for 3 weeks

Perioral dermatitis

250-500 mg PO twice daily for at least 30 days

125-250 mg PO 4 times daily for at least 30 days

Pinta

500 mg PO 4 times daily for 15 days

8 mg per kg daily divided into 4 doses for 15 days

Pitted keratolysis

250-500 mg PO 4 times daily for 10 days

30-50 mg per kg daily divided into 4 doses for 10 days

Pityriasis lichenoides

500 mg PO twice daily

30-50 mg per kg daily divided into 2 doses

Pityriasis rosea

500 mg PO 4 times daily for 2 weeks

30-50 mg per kg daily divided into 4 doses for 2 weeks

Relapsing fever (louse-borne)

500 mg PO for 1 dose

250 mg PO for 1 dose

Relapsing fever (tickborne)

500 mg PO 4 times daily for 7 days

30-50 mg per kg daily divided into 4 doses for 7days

Rosacea

250-500 mg PO twice daily for at least 30 days

125-250 mg PO 4 times daily for at least 30 days

Scarlet fever

500 mg PO 4 times daily for 7-10 days

30-50 mg per kg daily divided into 4 doses for 10 days

Syphilis

500 mg PO 4 times daily for 2-4 weeks

30-50 mg per kg daily divided into 4 doses for 2-4 weeks

Syphilis

500 mg PO 4 times daily for 2-4 weeks

30-50 mg per kg daily divided into 4 doses for 2-4 weeks

228 Erythroplasia of Queyrat

Erythromycin, systemic. Dermatologic indications and dosage (Continued)

Disease

Trench fever Yaws

Adult dosage

Child dosage

500 mg PO 4 times daily for 4 weeks 30-50 mg per kg daily divided into

3 doses for 15 days

500 mg PO 4 times daily for 15 days 30-50 mg per kg daily divided into

4 doses for 15 days

Contraindications/precautions

Hypersensitivity to drug class or component; caution about resistant organisms when used without benzoyl peroxide

References

Greenwood R, Burke B, Cunliffe WJ (1986) Evaluation of a therapeutic strategy for the treatment of acne vulgaris with conventional therapy. British Journal of Dermatology ii4(3):353-358

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