Fluorouracil topical

Trade name(s)

Efudex; Fluoroplex; Carac; Adrucil

Drug class

Antimetabolite

Mechanism of action

Inhibition of DNA synthesis by blocking thymidylate synthetase

Dosage form

0.5% cream; 1% cream; 5% cream; 1% solution; 2% solution; 5% solution; 50 mg/ml solution for intralesional injection

244 Fluoxetine

Fluorouracil, topical. Dermatologic indications and dosage

Disease Adult dosage Child dosage

Actinic keratosis Apply 1-2 times daily for 3-6 weeks Apply 1-2 times daily for 3-6 weeks

Basal cell carcinoma Apply 1-2 times daily for 4-8 weeks Not applicable

Basal cell nevus Apply 1-2 times daily for 4-8 weeks Apply 1-2 times daily for 4-8 weeks syndrome;

Bowenoid papulosis Apply 1-2 times daily for 4-8 weeks Not applicable

Carcinoma-in-situ Apply 1-2 times daily for 4-8 weeks Not applicable (Bowen's disease)

Disseminated Apply twice daily for 4-8 weeks Apply twice daily for 4-8 weeks superficial actinic porokeratosis

Hyperkeratosis lenticularis perstans Keratoacanthoma

Apply 2 times daily for 2-4 months Not applicable

50 mg per ml intralesional injection; Not applicable repeat every 2 weeks for up to 5 times

Wart Apply twice daily for 6 weeks Apply twice daily for 6 weeks

Dermatologic indications and dosage

See table

Common side effects

Cutaneous: local pain, pruritus, burning, crusting, erosions, allergic contact dermatitis, photosensitivity, hypopigmentation, hyperpigmentation

Serious side effects

None

Drug interactions

None

Contraindications/precautions

Hypersensitivity to drug class or component; avoid excessive sun exposure while in use

References

Jeffes EW 3rd., Tang EH (2000) Actinic keratosis. Current treatment options. American Journal of Clinical Dermatology 1:167-179

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