Human disease associated only with Cryp-tococcus neoformans; following inhalation of the organism, alveolar macrophages ingest the yeast; cryptococcal polysaccha-ride capsule has antiphagocytic properties and may be immunosuppressive; anti-phagocytic properties of the capsule block recognition of the yeast by phagocytes and inhibit leukocyte migration into the area of fungal replication; decreased host immunity main element in susceptibility to clinical infection; organ damage primarily from tissue distortion secondary to increasing fungal burden

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