Pathogenesis

Occlusion of the skin, due to clothing or bandages, resulting in pooling of sweat on the skin surface and overhydration of the stratum corneum; in susceptible persons, including infants, with relatively immature eccrine glands, stratum corneum overhydration causes transient blockage of the acrosyringium, resulting in leakage of sweat; other contributing factors: immatu rity of the sweat ducts in neonates, lack of acclimitization, occlusive clothing, hot and humid conditions, vigorous exerciose, and bacterial overgrowth

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