Irritant variant: caused by direct injury of the skin by an agent capable of producing

Contact dermatitis. Erythematous, edematous plaques around the eyes in a patient with an allergic contact dermatitis to a topical eye medication

cell damage in any individual if applied for sufficient time and in sufficient concentration

Allergic variant: type IV hypersensitivity reaction only affecting previously sensitized individuals

Contact urticaria variant: possibly immu-nologic in some cases

Photocontact variant: irradiation of certain substances by light resulting in the transformation of the substance into full antigens (photoallergic) or irritants (phototoxic)

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