Serious side effects

Eye: decreased night vision Neurologic: spinal hyperostosis, pseudotumor cerebri, mood disorder Gastrointestinal: hepatotoxicity, pancreatitis

Isotretinoin 313

Isotretinoin. Dermatologic indications and dosage

Disease

Adult dosage

Child dosage

Acne conglobata

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Acne necrotica

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Acne vulgaris

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Basal cell nevus 0.5 mg/kg PO daily for 1 month 0.5 mg/kg PO daily for 1 month syndrome followed by 1 mg/kg daily for followed by 1 mg/kg daily for

4-6 months 4-6 months followed by 0.5-1.0 mg/kg daily followed by 0.5-1.0 mg/kg daily indefinitely indefinitely

Dissecting cellulitis of the scalp

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Eosinophilic pustular folliculitis

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Gram negative folliculitis

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Hidradenitis suppurativa

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Keratosis pilaris atrophicans

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Lamellar ichthyosis

0.2-0.3 mg/kg PO daily for 1 month, followed by 0.5-1.0 mg/kg daily indefinitely

0.2-0.3 mg/kg PO daily for 1 month, followed by 0.5-1.0 mg/kg daily indefinitely

Lichen sclerosus

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Lupus erythematosus, discoid

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Muir-Torre syndrome

0.5-1.0 mg per kg PO indefinitely

0.5-1.0 mg per kg PO indefinitely

Basal cell nevus 0.5 mg/kg PO daily for 1 month 0.5 mg/kg PO daily for 1 month syndrome followed by 1 mg/kg daily for followed by 1 mg/kg daily for

4-6 months 4-6 months

Chloracne

0.5 mg/kg PO daily for 1 month

0.5 mg/kg PO daily for 1 month

followed by 1 mg/kg daily for

followed by 1 mg/kg daily for

4 months

4 months

Darier disease 0.2-0.3 mg/kg PO daily for 1 month, 0.2-0.3 mg/kg PO daily for 1 month,

Darier disease 0.2-0.3 mg/kg PO daily for 1 month, 0.2-0.3 mg/kg PO daily for 1 month, followed by 0.5-1.0 mg/kg daily followed by 0.5-1.0 mg/kg daily indefinitely indefinitely

Isotretinoin. Dermatologie indications and dosage (Continued)

Disease

Pityriasis rubra pilaris

Adult dosage

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Child dosage

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Reactive perforating collagenosis

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4 months

Rosacea

10-20 mg PO daily for 4-6 months

Not indicated

Sebaceous gland hyperplasia

10-20 mg PO daily or every other day indefinitely

Not indicated

Steatocystoma mutiplex

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4-6 months

0.5 mg/kg PO daily for 1 month followed by 1 mg/kg daily for 4-6 months

T-cell lymphoma, cutaneous

1 mg per kg PO daily for 4-6 months

1 mg per kg PO daily for 4-6 months

Transient acantholytic 0.5-1.0 mg per kg PO daily for Not applicable dermatosis 4-5 months

Transient acantholytic 0.5-1.0 mg per kg PO daily for Not applicable dermatosis 4-5 months

Genitourinary: major birth defects; pseudotumor cerebri

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