Sebaceoma

Synonym: Sebaceous epithelioma (old term). Clinical Presentation:

■ Solitary yellowish circumscribed nodule or an ill-defined plaque (Fig. 10A)

■ Usually on the face or scalp

■ May be multiple in Muir-Torre syndrome

Histopathology:

■ Usually small size, symmetric, and well-circumscribed (Figs. 10B and 11A)

■ Broad histologic spectrum

■ Aggregations of neoplastic cells with great variation in size and shape (Figs. 10B and 11A) (1)

■ Sebaceous lobules comprised of small, undifferentiated basaloid cells and mature sebocytes. The ratio of basaloid undifferentiated sebocytes to mature sebocytes varies from case to case as well as from field to field in the same case (Figs. 10C; 11B, C, and D)

■ The basaloid cells in the sebaceous aggregates outnumber the mature sebaceous component (Figs. 10C; 11B and C) (1,2)

■ Mitoses may be numerous but not atypical (Fig. 11D)

■ Sebaceous duct-like structures seen throughout the aggregates (Fig. 10D) (1,2)

Clinicopathologic Correlation:

Clinical Feature

Pathologic Feature

Well-demarcated shiny yellowish papule with a central dell

Dilated follicular infundibulum surrounded by large sebaceous lobules

Reference:

1. Schirren CG, Jansen T, Lindner A, et al. Diffuse sebaceous gland hyperplasia. Am J Dermatopathol 1996; 18:296-301.

Reference:

1. Schirren CG, Jansen T, Lindner A, et al. Diffuse sebaceous gland hyperplasia. Am J Dermatopathol 1996; 18:296-301.

224 Lazova Clinicopathologic Correlation:

Clinical Feature Pathologic Feature

Yellow or flesh-colored Well-circumscribed and symmetric circumscribed nodule or lesion comprised of sebaceous lobules an ill-defined plaque and aggregates with great variation in size and shape, in which immature sebocytes predominate

Clinicopathologic Correlation:

Clinical Feature

Pathologic Feature

Poorly defined erythema-

Asymmetrical neoplasm with infiltrative

tous or yellowish nodule or

borders comprised of large irregular

plaque

aggregates of neoplastic sebocytes that

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