Recently, a promising therapeutic strategy has been to attack the irreversible intermolecular AGE crosslinks formed in biological systems providing prevention or reversal of various diabetes- and aging-related complications. This approach aims to "break" preaccumulated AGE and help renal elimination of resulting smaller peptides. PTB was originally studied (187) and more recently ALT-711 (8,13,188). Long-term studies are in progress to establish the safety of this new category of anti-AGE agents
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