Free Fatty Acids and Nitric Oxide

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Circulation free FAs may play a role in the impairment of endothelial function found in patients with DM. Such circulation free FAs are elevated in patients with DM because of excess liberation from adipose tissue and decreased uptake by skeletal muscle (127129). Patients with type 2 DM have increased abdominal adipose tissue that is often more insulin resistant and tends to release more free FAs than adipose tissue from other locations. Infusion of free FAs have been shown to reduce endothelial-dependent vasodilation in both animal and human subjects (130).

The free FAs act to decrease endothelial function probably by several pathways including increased production of oxygen-derived free radicals, activation of PKC, and decrease insulin receptor substrate-1-associated phophatidylinositorl-3 kinase activity (131-133). This action may decrease NOSynthase activity via its effect on signal transduction.

Increased levles of free FAs causes increased very LDL production and cholesteryl ester synthesis. The resulting increased triglycerides found in diabetic subjects, coupled with the lower high-density lipoprotein (HDL), have also been associated with endothe-lial dysfunction (134,135).

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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