Natural Dietary Supplements

Inner Peace Formula

The formula product of nutrition blends-inner-peace is well known, it is a remedy for plants used for a wide range of problems. In oncology, it is especially recommended as a topical treatment to prevent or treat skin irritations after radiotherapy. The product is a succulent plant with many amazing uses, it is then applied topically to the skin and hair or ingested. The product can also be combined with other natural ingredients to be part of your health or beauty routine. The product is scientifically proven the ingredients used in the Inner Peace formula have been specifically chosen because of scientific studies proving that they have the power to significantly improve the health and well-being of the individual. For decades, the soothing nature of nutrition blends-inner-peace formula has been known and respected by the people who believe in naturopathy. The product has compounds such as ashwagandha, magnolia, hops,l-Theanine, Passion Flower, Panax Ginseng, Hawthorn Berry that are extremely beneficial for human health. It has 18 amino acids that work in association with other compounds of the human body to deliver numerous health benefits. It has been reported extensively that Panax Ginseng supports the immune system by enhancing the body's resistance to illness and microbial attacks. Read more here...

Inner Peace Formula Summary


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Definitions of dietary supplements

The DSHEA defines dietary supplements for regulatory purpose within the United States. The Office of Dietary Supplements at the NIH needed to implement research priorities using this definition and yet in some manner group the wide array of supplement ingredients available in the marketplace into more manageable categories. A definition was needed that also could be interpreted more readily in terms of research projects. An operating definition was requested in meetings with the NIH Institute Directors and other agencies who expressed difficulty in understating whether or not specific ingredients would be supported in the research and education programmes developed by the ODS. The resulting operating definition and categorization of dietary supplement ingredients was developed in collaboration with the staff of the Office of Special Nutritionals at the Food and Drug Administration (FDA), who had oversight for dietary supplement regulatory affairs, and a large group of ad hoc advisers...

The Office of Dietary Supplements at the National Institutes of Health

The Office of Dietary Supplements (ODS) was authorized at the NIH as part of the DSHEA legislation. This office was formally started in late 1995 with the mandate to serve as a source of research support, inter-government advice, and science-based information on dietary supplements. The ODS has worked extensively with the other NIH institutes, centres and offices to partner in identifying the most fruitful areas for research in dietary supplements and to serve as a source of information for scientists, industry and the public. While the Congressional mandate for the ODS was specified broadly, the office staff needed to take this mandate and transform it into specific achievable goals and objectives. In order to do this, the office assembled over 125 scientists and professionals from academia, government, industry and public-interest groups and held a series of seven strategic planning meetings in autumn and winter 1996 1997. Different individuals were involved in each of the seven...

A brief overview of dietary supplement ingredient regulation in the United States

In 1994 the United States Congress passed the Dietary Supplement Health and Education Act (DSHEA, Public law 103-417, October 25, 1994, 103rd Congress). This law modified the Food, Drug, and Cosmetic Act and expanded the definition of dietary supplements to include botanical ingredients, hormones, and a diverse array of related products in addition to vitamins and minerals. The DSHEA also specified the role of the United States Food and Drug Administration (FDA) in regulating dietary supplements, mandated the creation of a Presidential Commission on Dietary Supplement Labeling, and authorized the establishment of the Office of Dietary Supplements at the National Institutes of Health (NIH). The main elements of the definition of dietary supplements from the DSHEA are listed in Box 1.1. For products that are regulated by the FDA, the 'intended use' of a product or ingredient is the turnkey that determines whether an item is broadly classified as a food or a drug. Dietary supplements, no...

Sales and use of dietary supplements in the United States

The sale and use of dietary supplements in the United States initially grew dramatically after the passage of the DSHEA. Figures of individual and mixtures of botanical supplements drove the market. The growth and demand led to a consolidation of manufacturing and retail corporations as well as new growth in botanical supplements produced by the major pharmaceutical corporations in the US. It is estimated that from 30 53 per cent of Americans or 100 million people use dietary supplements on a regular basis (several times each week) (Aarts, 1998). In 1996 sales of dietary supplements totalled 9.8 billion and represented 51 per cent of the total sales in the nutrition industry in the United States. Sales of dietary supplements in natural food stores comprised 44 per cent of the total, and mass-market retail accounted for 26 per cent of the total with the remainder in direct marketing through the mail or Internet. Overall sales for dietary supplements grew 9 per cent in 1996 (Aarts,...

The chapters that follow

In 1994 or the establishment of the European Scientific Cooperative on Phytotherapy (ESCOP) in 1989. These scientists present a comprehensive view of the earlier and current approaches to studying plant-derived compounds that are used as dietary supplements. They also have placed their research into the worldwide perspective of plant biodiversity, ecology and the increasingly politically fraught arena of genetically modified foods. Dr Can Baser approaches dietary supplements of plant origin from the perspective of the plant industry in Chapter 4. He discusses the active compounds with potential health benefits in a number of food products such as soybeans, tomatoes, etc. Marco Mucciarelli begins his chapter (Chapter 6) with a clearly written description of the tools and techniques currently used in plant biotechnology. Dr Mucciarelli then details the research history and current knowledge base of the biotechnological advances with plants used for herbal medicines and dietary...

The situation in Europe

In Europe, dietary supplements account for 15 20 per cent of the herbal market. Although regulations vary from country to country, in Europe, herbal products are generally considered as medicines. Therefore, full registration with a full dossier on quality, safety and efficacy has to be submitted for pre-market approval. Bibliographic documentation can be based on clinical trials, and the monographs of the European Pharmacopoeia (EP), World Health Organization (WHO), German Commission E and the European Scientific Cooperative on Phytotherapy (ESCOP). There is a simplified way of registering a herbal product as medicine with proof of efficacy based on long-term traditional use in countries like Germany, Austria, Belgium and France. In such a case, the medicine has to carry a disclaimer on the label stating that it is 'traditionally used' (Lawson and Bauer, 1998 Stott, 1998 Grunwald, 1999 Steinhoff, 2001). In short, the EU has, at present, no legislation like in the USA to regulate...

Main techniques employed by plant biotechnology

Plant secondary metabolism is very important in determining flower colour, flavour of food, and plant resistance against pests and diseases. Moreover, it is the source of many useful chemicals such as drugs, dyes, flavours and fragrances (Verpoorte et al., 1999, 2000), which are the main active constituents or at least simple components of most medicinal plants and herbal dietary supplements. Therefore, it is of interest to be able to engineer the secondary metabolite production of the plant cell factory, e.g. to produce more of a useful chemical, to produce less of a toxic compound, or even to make new compounds or valuable herbal products. Our limited knowledge of secondary metabolite pathways and the genes involved is one of the main bottlenecks (Verpoorte et al., 2000).

Official information resources

The section on official sources of information includes reviews (monographs) by officially recognized experts on botanicals such as the United States Pharmacopoeia, World Health Organization Traditional Medicine Programme and the European Scientific Cooperative on Phytotherapy. It also includes information resources from governmental organizations such as the Office of Dietary Supplements at the National Institute of Health.

Biosynthesis Of Hypericin

Hydroxycinnamoyl Coa Malonyl Coa

Dietary supplements of ephedrine plus caffeine for weight loss (weight loss being the current first-line recommendation of physicians for osteoporosis) show some promise, but are not sufficient in number of study subjects. Ephedrine is a sympathomimetic amine with effects similar to those of adrenaline it is produced by Ephedra (or ma huang), which has been used by the Chinese for at least 5,000 years. Ephedrine has resulted in deaths and hence is worrisome as an over-the-counter dietary supplement (Fillmore et al., 1999). Ephedrine has been described as a causative factor of vasculitis but myocarditis has not yet been associated with either ephedrine or its plant derivative ephedra (Zaacks et al, 1999). The content of ephedra alkaloids in herbal dietary supplements containing Ephedra (ma huang) has been studied by Gurley and co 2003 Taylor & Francis Ltd Determination of cyanogenic glycoside content in dietary supplements is done by means of qualitative, semi-quantitative or...

The example of St Johns wort

Increasing numbers of people are seeking symptomatic relief of psychiatric disorders by using dietary supplements. Since this is generally without medical supervision (Fugh-Berman and Cott, 1999 Wong et al., 1998), it is essential that clinicians avail themselves of the extensive literature available on natural products so that potential problems can be avoided. Herb drug interactions can be of two primary types pharmacokinetic and pharmacodynamic. Dynamic interactions are those having to do with the mechanism of action, e.g. where the drug's pharmacologic actions may be in opposition to or in addition to one another. Pharmacokinetic interactions are the result of alterations in the absorption, distribution, metabolism or excretion of medications when given together with specific drugs, foods or supplements. Interactions between botanical products and prescribed medications could increase or decrease the action of the drug, though the majority of interactions are likely to go...

Transgenic crops for improved medicinal plants and pharmaceutical products

As discussed earlier, secondary metabolite pathways are complicated, since they require multiple enzymatic steps to the desired end-product used as therapeutic substance or dietary supplement and since these enzymatic pathways are under the control of multifactorial regulatory processes.

Concluding remarks

Chang, J. (2000) Medicinal herbs drugs or dietary supplements Biochem. Pharmacol., 59, 211-219. Heber, D. (1999) Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am. . Clin. Nutr., 69, 231-236. Israelsen, L.D. (1999) Federal court upholds dietary supplement status of Cholestin. Herbalgram, 46, 26-28.


Dietary supplements in the United States include a wide array of ingredients and products that are broadly available in the marketplace. While these products are presented in formats that give the appearance of standard over-the-counter (OTC) medications such as aspirin, their manufacturers are not required to provide the same level of pre-market safety data as manufacturers of OTC products. Botanical supplements, in particular, are directly derived from wild, or in some cases, commercially grown plants and therefore are more subject to product variability due to plant contamination, and manufacturing and post-manufacturing variables that are currently not regulated. The United States and countries within Europe have widely differing approaches to regulation and marketing of dietary supplements of plant origin. While these aspects may differ, scientists worldwide share concern with the need for careful hypothesis-driven research on the efficacy and safety of dietary supplements, and,...

The European market

Due to the uncertain interpretation of rules and the lack of a harmonized legislation, anyone who has ever tried to market food supplements containing herbs, having in mind to sell the same product in the majority of EU countries, will experience the range of complications and practical difficulties which may arise. For instance, the first problem may be the legal status of the herbal product in certain countries it will be deemed as a medicine, in others as a food or a food ingredient. Talking about dietary supplements in Europe means considering both the above-mentioned categories because of the different legal basis that a single product can have in different states. As a matter of fact, we must not limit our discussion to food products. From the description of a herbal product as a medicine or as a food can derive the practical feasibility of marketing it in a number of countries. A good example of this can be marketing a Ginkgo biloba product, claiming its capability to improve...

New terminology

The expanding world of dietary supplements especially in the USA, has learned new terminology such as 'functional foods', 'novel foods', 'nutraceuticals', 'designer foods', 'pharmafood', 'phytoceuticals'. These terms are used to describe At present, in the USA, there is no legislation governing the use of nutraceuticals or functional foods. The FDA states that existing regulations for foods are sufficient and that companies must decide on intended use (conventional food or dietary supplement) early in product development (Anon., 2000).


Biosynthesis Anthocyanins

Recently, a renewed interest in flavonoids has been fuelled by the antioxidant and oestrogenic effects ascribed to them. This has led to their proposed use as anticarcino-gens and cardioprotective agents, prompting a dramatic increase in their consumption as dietary supplements. Unfortunately, the potentially toxic effects of excessive flavonoid intake are largely ignored. At higher doses, flavonoids may act as mutagens, pro-oxidants that generate free radicals, and as inhibitors of key enzymes involved in hormone metabolism. Thus, in high doses, the adverse effects of flavonoids may outweigh their beneficial ones, and caution should be exercised in ingesting them at levels above that which would be obtained from a typical vegetarian diet. The unborn fetus may be especially at risk, since flavonoids readily cross the placenta. More research on the toxicological properties of flavonoids is warranted, given their increasing levels of consumption (Skibola and Smith, 2000). Compounds of...

Primary Nursing Diagnosis

Pharmacologic therapy may include IV saline solutions, potassium supplements, histamine antagonists, and carbonic anhydrase inhibitors. IV saline solutions (0.9 or 0.45 ) may be used to replace lost volume and chloride ions. Causes of metabolic alkalosis that respond favorably to saline therapy include vomiting, NG suctioning, post chronic hypercapnia, and diuretic therapy. The causes of metabolic alkalosis that do not respond favorably to the administration of saline include hypokalemia and mineralocorticoid excess. Potassium chloride is used to treat hypokalemia in a patient with metabolic alkalosis. Dietary supplements of potassium are not effective unless chloride levels are stabilized.

Descriptive Epidemiology of Herbal and Vitamin Poisonings

An herb is a leafy plant without a woody stem, but herbal preparations include all natural, alternative, and traditional remedies. Twenty-five percent of current, proprietary pharmaceuticals come from plant-herb sources. As a result of the Dietary Supplement and Health Education Act of 1994, the FDA has no authority over regulating herbal and vitamin products, unless they prove to be toxic. 80 of the world's population use herbal products and vitamins daily most are benign, and offer no health benefit (e.g., vitamin C and Echinacea) or potentially lethal drug interactions (e.g., St. John's wort and SSRIs garlic, ginkgo, and ginseng, and anticoagulants ASA, heparin, warfarin ).

Taking Supplements with Your Diet

Cium, because very-low-protein diets usually contain inadequate amounts of these substances. Almost any multivitamin suffices, unless it contains added phosphate. However, vitamin requirements for those with advanced kidney failure are different. Specially formulated multivitamin preparations are available. (See Appendix 1.)

Choose Reliable Herb Suppliers

When using herbs, it is important to purchase them from companies that produce high-quality, consistent preparations. Some of the highest quality preparations are produced in Europe. Brands chosen should be standardized and contain specified amounts of active ingredients. The product also should list other specific information common and scientific name of the herb, the manufacturer's name and address, batch and lot number, expiration date, dose recommendations, potential side effects, and quality control information. Higher-quality herbal products in the United States have the symbols for the United States Pharmacopeia (USP) or the National Formulary (NF). To evaluate the quality of some herbs and other dietary supplement products, independent laboratory evaluations of products have been done by Consumer Reports and by an organization known as ( The results of these evaluations are available from these sources.

Additional Readings Books

Austin American Botanical Council, 1998. Bowling AC, Stewart TS. Dietary Supplements and Multiple Sclerosis A Health Medicines. Philadelphia Lippincott, Williams, & Wilkins, 2004. Fragakis AS. The Health Professional's Guide to Popular Dietary Supplements. The

Initial Evaluation Of The Patient With Substance Use Disorders

Team and be used to develop the safest possible treatment plan. The clinician should ask about specific illicit substances such as heroin, cocaine, marijuana, and the club drugs (see below). For taking a history of alcohol use, some clinicians have suggested the use of the CAGE questionnaire (Ewing, 1984) 1. Can you cut down on your drinking 2. Are you annoyed when asked to stop 3. Do you feel guilty about your drinking 4. Do you need an eye-opener when you wake up in the morning One should also ask about sedative or stimulant use, whether prescribed or nonprescribed, and any dietary supplements or herbs the patient may be taking. A substance abuse review of systems, focusing on renal, cardiac, gastrointestinal, and, for HIV patients especially, neurological symptoms, is essential. Other points of inquiry are the date the substance was first used patterns, amount, and frequency of use and routes of administration and reactions to the use. The time of last use is important to know to...

Prevention and Optimization

Initial preoperative assessment of nutritional status includes weight (loss of 10 ideal body wt is significant), albumin, and protein levels. Patients with poor nutrition can undergo counseling about adequate vitamin supplementation and the use of high-protein or high-calorie nutritional supplements. For patients who are significantly malnourished or dehydrated, we place a nasogastric tube preoperatively and commence tube feedings. We do not routinely employ preoperative gastrostomy tube placement, except for those patients in whom we anticipate prolonged aspiration or postoperative dysphagia. Postoperative nutritional status is monitored with weight gain and serum prealbumin levels, which are thought to be a more sensitive indicator of nutritional status than albumin alone.

Nutritional evaluation of foods

* Supplementation results from the consumption of nutritional supplements such as vitamin and mineral tablets. Fortification is the addition of nutrients to standard foods (e.g., breakfast cereals) particularly those which may have lost some nutrient content as a result of processing.

Social Cultural And Economic Context Of The Disaster

In addition to the health concerns and other societal strains raised by the accident and the response measures that were put in place, the disaster had serious socioeconomic consequences. In Belarus, the most seriously affected of the three adjacent republics, 38,000 square kilometers, or 18 of the land area of this republic, was more or less severely contaminated, especially by radioactive cesium-137, which has a half-life of 30 years. In this republic, 300,000 hectares of farmland were taken out of production for this reason. Some 1 million hectares of the forests were contaminated to varying degrees 1 . The population was advised not to eat mushrooms or berries from these forests, thereby depriving them of an otherwise welcome dietary supplement and favorite pastime. In addition to losses in agricultural production, the market for food products from the region was completely lost, as was tourism, another major source of income in some districts. The affected parts of Ukraine and...

Prevention of dementia I

At least five clinical trials are currently underway specifically to examine the role of vitamins C and E and other antioxidants in preventing memory decline and Alzheimer's disease until the results of these trials are available, it is unknown whether vitamin supplements will prevent Alzheimer's disease.

Epa And Dha Possess Different Metabolic Properties

Besides lowering plasma lipids and the apparent protection in thrombosis, dietary supplements enriched in omega-3 fatty acids have proved to lower blood pressure, alter lipoprotein metabolism and dampen platelet aggregation among other beneficial effects in humans.810 The two components of fish oil attracting the most attention, namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are still often referred to as omega-3, or n-3 fatty acids without any further distinction. Nearly all studies that have been conducted have used a mixture of EPA and DHA. It has, however, been reported that DHA are retroconverted to EPA in cultured hepatocytes,11 rat12 and man13 and it is, therefore, conceivable that EPA and DHA possess different metabolic

Patients with Polycystic Kidney Disease

Doris Balboni, a 67-year-old retired nurse with polycystic kidney disease, was found to have severe renal failure, with a glomerular filtration rate of 10.2 ml per minute and a serum creatinine concentration of 4.2 mg per dl. She was placed on a very-low-protein diet supplemented alternately by an essential amino acid mixture and by a ketoacid amino acid mixture, both devoid of tryptophan. (Tryptophan was omitted because the Food and Drug Administration had decreed that it could not be used as a dietary supplement until the cause of a severe form of muscle disease, related to one particular commercial source of tryptophan, was clarified.) Serum tryptophan concentration fell, reaching a low of 4.16 uM (normal

Antioxidant Vitamins Generally Vitamins A C and E

Among all categories of dietary supplements, antioxidant vitamins were among those used most frequently by a large group of people with MS who were surveyed through a study at the Rocky Mountain Multiple Sclerosis Center (the full results of this survey may be seen at Antioxidant vitamins include If people with MS choose to use antioxidant vitamin supplements, it is reasonable to take modest doses. Modest daily doses of these vitamins are

Coenzyme Q And Atherosclerosis

Appears to be a safe dietary supplement with no reported side effects, although long-term studies with relatively high doses (100 to 200 mg day) remain to be carried out. In atherosclerotic lesions, CoQ10H2 has not been detected despite normal concentrations of total coenzyme Q being present.95 However, any remaining CoQ10H2 may have autoxidized during sample preparation. If coenzyme Q is present predominantly as CoQ10 in the arterial wall, then this would increase the susceptibility of lipoproteins to oxidation. A recent study111 using apolipoprotein E knockout mice fed a high fat diet has reported that aortic coenzyme Q content decreases proportionally to a-TOH as the atherosclerotic lesions develop. This, too, may increase the susceptibility of lipoprotein lipids to oxidation.18 However, dietary supplementation of these mice with coenzyme Q10 can increase aortic coenzyme Q up to 10 times thereby rectifying the imbalance with a-TOH seen in unsupplemented mice.62

Essential Amino Acid Supplements

These preparations, as well as pure amino acids, are considered dietary supplements and are therefore not subject to regulation by the Food and Drug Administration. The advantage is that they are readily available the big disadvantage is that most insurers won't reimburse you for the cost. However, reimbursement for these products by Medicaid has been granted in several states.

Dehydroepiandrosterone DHEA

DHEA (dehydroepiandrosterone) is a hormone available as a dietary supplement. It is marketed as an antiaging compound and as a miracle cure for many medical conditions. Claimed benefits of DHEA of potential interest to people with MS include improvement in fatigue, sex drive, and mood.

Treatment Method

Two groups of chiropractors are recognized straights and mixers. Straights use only spinal manipulation. Mixers, who represent the majority of chiropractors in the United States, use manipulation techniques and other measures, which may include ultrasound, massage, herb or vitamin supplements, and dietary recommendations.


In most settings, the primary purpose of drug testing is to identify individuals who are using illegal or illicit drugs. Falsely accusing someone of using drugs is highly problematic and undermines the testing program. Similarly, not being able to identify active drug users because of false-negative results renders a program of limited value. It does not deter use or identify users. This is so both for the emergency room physician wondering if the agitated patient used PCP, and for the consultant to the local college track team. For these situations, highly sensitive qualitative screening tests should be employed, even if this leads to some false-positive results. On the other hand, definitive tests should have the highest level of specificity They should exclude as many true negatives as possible. For nonusers who are subjected to drug testing, issues related to false-positive results are of great concern. Questions addressing which foods, prescribed medications, dietary supplements,...


Q is widely used as a dietary supplement and in a variety of clinical therapies (the nutritional aspects of Q and the use of Q in clinical therapies are topics of discussion in later chapters of this volume). In most studies with young rats, dietary Q results in increased Q levels in blood (including lipoproteins) and liver, but has little effect on Q levels in other tissues.140 Recently however, supplementation with Q in aged rats has been reported to improve age-associated arterial dysfunc-tion,141 stress tolerance and baseline heart function,142 and to provide neuroprotective effects that correlated with significant increases in Q content in brain mitochondria.143

Club Drugs

GHB was initially developed as an anesthetic but was found to have too many side effects to be used regularly. In the club scene, GHB is taken for its sedating and euphoric effects. It has also been used as a date-rape drug, leading to concerns of HIV exposure through unprotected sexual intercourse. Because of its amnestic effects, the victim may not even know that they have been exposed. GHB has a relatively narrow therapeutic range its toxic effects include seizures, coma, and death. In addition, a severe withdrawal syndrome among chronic users has been reported (Bialer, 2002). Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4- BD) are precursors that can be converted to GHB after ingestion. They are available in a variety of dietary supplements for purported but un-proven anabolic effects. Camacho et al. (2004) showed


ULs arc useful because of the increased interest in and availability of fortified foods, the increased use of dietary supplements, and the growing recognition of the health consequences of excesses, as well as inadequacies, of nutrient intakes. ULs arc based on total intake of a nutrient from food, water, and supplements if adverse effects have been associated with total intake. However, if adverse effects have been associated with intake from supplements or food fortifi-cants only, the UL is based on nutrient intake from those sources only, not on total intake. The UL applies to chronic daily use.


Pycnogenol has been used as a dietary supplement for approximately 15 years. It is made from the bark of the French maritime pine tree. Pycnogenol is a mixture of chemicals known as oligomeric proanthocyani-dins (OPCs). These chemicals, which are similar to those in grape seed extract and green tea leaves, appear to act as antioxidants.

SHE study

Soy Health Effects Study (SHE) conducted under a National Institutes of Health grant to study the potential benefits of a dietary supplement of soy on the health of postmenopausal women. Subjects for the study consisted of women aged 45-74 y who attended screening and baseline visits and were subsequently enrolled in the Soy Health Effects (SHE) Study. The SHE Study is a randomized, double-blind, placebo-controlled trial designed to investigate the extent to which isoflavone use improves heart disease risk factors, bone density and quality of life in postmenopausal women. To be eligible for the SHE Study, women had to be at least 2 y postmenopausal, not using HRT for _ 3 mo, and not currently using lipid-lowering drugs, antidiabetic medications, tamoxifen, or soy protein or herbal supplements. Women with a history of uncontrolled hypertension, stroke or transient ischemic attack, cancer diagnosed


Many researchers have hypothesized that supplementation with ubiquinone-10 (Q10) may enhance athletic performance.3,61718 Based on current knowledge regarding the function of Q10 in human muscle cells, these are valid theoretical speculations. Some in vitro data can also be interpreted in favor of beneficial effects on cell function of increased Q10 concentrations in working muscle cells.19,20 Caution must always be taken when extrapolating in vitro data to in vivo situations. For example, direct intravenous injection with high Q10 concentration (10 mg kg) in isolated rabbit heart in the study by Takeo et al.,20 or direct administration of Q10 in cultured rat muscle cells followed by electric stimulation19 might not be of physiological relevance. In these situations, Q10 is administered directly into the muscle tissue and concerns regarding physiological uptake and availability are avoided. The majority of the data so far published demonstrates no positive effects of oral Q10...


Androstenedione became well known to the public after the baseball player Mark McGwire acknowledged that he used it in 1998. Androstenedione is a hormone sold as a dietary supplement. In the body, it is converted to testosterone, the male sex hormone. Androstenedione is of potential interest to people with MS because it is claimed to increase strength and energy.


Based on current knowledge from published data, the hypotheses on positive effects of Q10 supplementation on physical performance in healthy men cannot be verified. Regarding the effects on women, no data are available. The laborious task of conducting studies including larger numbers of subjects (men and women) in well-designed studies remains for future research. This holds true also for other nutritional supplements, including other antioxidants. To Q or not to Q, that is the question.

Supplements and MS

Supplements are one of the most popular forms of CAM used by people with MS. The largest and most detailed survey of dietary supplement use among people with MS was conducted at the Rocky Mountain Multiple Sclerosis Center. Of the respondents to this survey, more than 90 percent had used dietary supplements since being diagnosed with MS, and more than 80 percent were using some type of dietary supplement at the time of the survey. The full results of the survey are available at, the CAM website of the Rocky Mountain Multiple Sclerosis Center.

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