Substantia Nigra Neurons

Although Dale offered a very good lead in the peripheral nervous system to search for putative transmitters released from dendritic processes, it was the central nervous system which offered us the first unequivocal example of such a phenomenon. A great deal of this is due to the cytoarchitecture of the substantia nigra (SN) dopaminergic cell neurons. The majority of their cell bodies are neatly packed in the SN pars compacta, and their axonal processes project dorsally and rostrally toward the...

References

M., and Wang, R. Y., 1977, Evidence for norepinefrine-mediated collateral inhibition of locus coeruleus neurons, Brain Res. 136 570. Alreja, M., and Aghajanian, G. K, 1991, Pacemaker activity of locus coeruleus neurons whole-cell recordings in brain slices show dependence on cAMP and protein kinase A, Brain Res. 556 339. Alvarez-Maubecin, V., Garcia-Hemandez, F., Williams, J. T., and Van Bockstaele, E. J., 2000, Functional coupling between neurons and glia, J....

Regulation Of Somatodendritic Dopamine By Uptake Transporters

Plasma membrane uptake of DA by the DA transporter DAT is fundamental to the regulation of DA 0, such that DAT-mediated uptake, coupled with diffusion, defines the sphere of influence of somatodendritically, as well as synaptically released DA Cragg et al., 2001 Cragg and Rice 2004 . Electrophysiological studies suggest a physiological role for uptake in the modulation of somatodendritic DA 0 Lacey et al., 1990 . Regulation of DA 0 by uptake differs between the SNc and VTA, however. Ventral...