Other Target Classes

In 1997, Drews and Ryser summarized what they termed classic drug targets.448 These targets of marketed drugs were broken down into 11 classes comprising about 500 targets (Table 23). Receptor targets dominated these numbers, being twice as common for marketed drugs as enzyme targets, followed by factors and hormones, channels or unknown targets, and nucleic acid targets. Central nervous system (CNS) and related targets were the most common. How have we done in various therapeutic and target...

Figure 63 Chemical structures of carnitine and uric acid

Been discussed in the context of gene polymorphisms associated with several neuropsychiatry diseases or symptoms. For example, a 44 base pair insertion in SERT has been associated with psychosis and aggression.417 The primary site of action of SSRIs is now well known to be SERT.4118 As cited earlier, because patients with depression and related illnesses respond so variably to SSRIs, a number of studies have been undertaken to determine whether there is a genotypic explanation for the large...

Info

At the other end of the scale, the sometimes unrealistic wishes of company founders may not support the valuations of small biotech companies.15-16 Given these financial and other issues, the sustainability of the industry has been called into question, with the need for each major pharmaceutical company to produce a blockbuster at least once a decade to remain healthy financially, and in the face of continuing safety issues and withdrawals of major marketed...

Comprehensive Medicinal Chemistry II Volume 2 Strategy and Drug Research

Taylor and David J. Triggle ISBN 0-08-044513-6 2.01 The Intersection of Strategy and Drug Research, Pages 1-84, W.H. Moos 2.02 An Academic Perspective, Pages 85-97, D.J. Triggle 2.03 An Industry Perspective, Pages 99-135, W. Wierenga Organizational Aspects and Strategies for Drug Discovery and Development 2.04 Project Management, Pages 137-158, Y. Nakagawa and L. Lehman 2.05 The Role of the Chemical Development, Quality, and Regulatory Affairs Teams in Turning a Potent...