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Biography

Samuel E DePrimo received a BSc in biology from King's College in Wilkes-Barre, PA, and in 1996 received his PhD from the University of Cincinnati College of Medicine, where he developed and studied transgenic mouse models for the detection of somatic mutations in the laboratory of James Stringer. This was followed by postdoctoral work in George Stark's laboratory at the Cleveland Clinic Foundation's Lerner Institute, studying p53 signaling pathways and forward genetics applications, and with James Brooks at the Stanford University School of Medicine, in collaboration with Patrick Brown, applying gene expression profiling in studying the biology of prostate cancer cells. Dr DePrimo joined SUGEN, Inc. in 2001, as a scientist in the Biomarkers group, and focused on translational research and analysis of molecular biomarkers in oncology clinical trials of receptor tyrosine kinase inhibitors. He joined Pfizer Global Research and Development at the La Jolla campus in 2003, where as a scientist in the Translational Medicine group he continues to focus on biomarker applications and translational biology, primarily in oncology drug development.

© 2007 Elsevier Ltd. All Rights Reserved Comprehensive Medicinal Chemistry II

No part of this publication may be reproduced, stored in any retrieval system or transmitted ISBN (set): 0-08-044513-6 in any form by any means electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers ISBN (Volume 3) 0-08-044516-0; pp. 69-85

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