Consequences Of Congenital Or Acquired Human Herpesvirus 6 And 7 Infections

Although more than 60 newborns with congenital or perinatal HHV-6 infections have been reported in large series (Table 1), most apparently are healthy and have no unusual features. Several case reports have described fetuses or infants with HHV-6 infection, yet most have no abnormalities. Aubin et al. (25) first described in utero infection with HHV-6. These investigators examined 52 electively aborted fetuses from HIV-infected women from France and noted one fetus (26 weeks) with HHV-6 DNA distributed throughout fetal tissues. No abnormalities were identified. One study from Japan identified HHV-6 antigens in tissues from 2 of 30 (7%) fetuses spontaneously aborted at 6-12 weeks; fetal abnormalities were not described (26). HHV-6 DNA has also been found in fetal tissues of two of eight cases (25%) of fetal hydrops (17 and 19 weeks of gestation) (27). However, both fetuses also had a chromosomal abnormality (Down syndrome and Turner's syndrome) possibly contributing to the hydrops. Fulminant hepatitis in two neonates (aged 3 and 5 days) has purported to be linked to congenital HHV-6 infection based on HHV-6 viremia in mother and baby (28); further documentation of HHV-6 infection of liver tissue was not performed in these cases. Because HHV-6 viremia may occur in asymptomatic neonates (29), there is some question whether these cases are attributable to HHV-6 infection. Illness resembling roseola has also been reported in one neonate (age 3 weeks) despite the presence of maternal HHV-6 antibodies (30). These studies clearly demonstrate that HHV-6 can be transmitted congenitally as early as 6-12 weeks of gestation, However, there is insufficient evidence indicating a characteristic clinical syndrome; most newborns appear healthy. No reports of congenital or acquired HHV-7 infections have appeared.

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Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

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