Although more than 60 newborns with congenital or perinatal HHV-6 infections have been reported in large series (Table 1), most apparently are healthy and have no unusual features. Several case reports have described fetuses or infants with HHV-6 infection, yet most have no abnormalities. Aubin et al. (25) first described in utero infection with HHV-6. These investigators examined 52 electively aborted fetuses from HIV-infected women from France and noted one fetus (26 weeks) with HHV-6 DNA distributed throughout fetal tissues. No abnormalities were identified. One study from Japan identified HHV-6 antigens in tissues from 2 of 30 (7%) fetuses spontaneously aborted at 6-12 weeks; fetal abnormalities were not described (26). HHV-6 DNA has also been found in fetal tissues of two of eight cases (25%) of fetal hydrops (17 and 19 weeks of gestation) (27). However, both fetuses also had a chromosomal abnormality (Down syndrome and Turner's syndrome) possibly contributing to the hydrops. Fulminant hepatitis in two neonates (aged 3 and 5 days) has purported to be linked to congenital HHV-6 infection based on HHV-6 viremia in mother and baby (28); further documentation of HHV-6 infection of liver tissue was not performed in these cases. Because HHV-6 viremia may occur in asymptomatic neonates (29), there is some question whether these cases are attributable to HHV-6 infection. Illness resembling roseola has also been reported in one neonate (age 3 weeks) despite the presence of maternal HHV-6 antibodies (30). These studies clearly demonstrate that HHV-6 can be transmitted congenitally as early as 6-12 weeks of gestation, However, there is insufficient evidence indicating a characteristic clinical syndrome; most newborns appear healthy. No reports of congenital or acquired HHV-7 infections have appeared.
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The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.