Cmc

1.05 ±0.59

20.05 ± 4.08

1.00 ± 0.24

1.00 ±0.31

The values are given as means ± S.D. for eight animals. The rats were treated for 5 days with the different fatty acids at a dose of 250mg/day/kg body weight, 'significantly different (P < 0.05) from CMC, and "significantly different from EPA.

The values are given as means ± S.D. for eight animals. The rats were treated for 5 days with the different fatty acids at a dose of 250mg/day/kg body weight, 'significantly different (P < 0.05) from CMC, and "significantly different from EPA.

general fatty acid oxidation.8,9 TTA was methylated in 2-position, and we fed rats 2-methyl TTA at the dose 15mg/d/kg body mass. This is a very low dose, and usually we give TTA at a dose ten times this dose to obtain increased fatty acid oxidation. As shown in Table 3, TTA and 2-methyl TTA at this low dose did not have any effect on the mitochondrial P-oxidation, CPT-I or CPT-II activity, and the plasma lipids were unchanged. However, the peroxisomal FAO activity increased significantly after administration of 2-methyl TTA compared to TTA. Thus, the increased peroxisomal P-oxidation (measured as FAO activity) in 2-methyl TTA fed rats did not cause any hypolipidaemic effect compared to TTA fed rats.

0 0

Post a comment