Comments On The DienoylcoA Isomerasereductase Pathway Vs EnoylcoA Isomerase Pathway

The elucidation of this novel pathway raised the question as to whether unsaturated fatty acids with odd-numbered double bonds are metabolized via one or both branches of the pathway (Fig. 2). Tserng and co-workers47 4" concluded that in rat the novel A3,5-A2'4-dienoyl-CoA isomerase 2,4-dienoyl-CoA reductase-dependent pathway is the dominant route, especially in liver mitochondria. Conversely, Shoukry and Schulz50 have shown by concentration-dependent and time-dependent measurements that the flux through the reductase-dependent branch (20%) was much slower than through the

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