n = 4

n = 2

n = 8

expression during gestation and activation after birth allow sufficient capacity to produce the peak plasma ketone body concentrations observed during the second or third neonatal day.

Plasma ketone body concentrations are found to be significantly lower in preterm neonates than those born at fullterm (>36wk gestation).19 The lack of ketogenesis observed in these preterm or small-for-gestational-age (SGA) infants appears to be related to immaturity, despite appropriate metabolic responses to delivery-stress during the first day and irrespective of plasma glucose, non-esterified fatty acids and hormone concentrations. It has been suggested that it may be accounted for by reduced expression of mHMG-CoA synthase.24

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