The effect of different concentrations of ERA and TTA on the growth of CaCo2 cells is shown in table 1. At 100pM, EPA reduced the proliferation of these cells by 34% and TTA by approximately 90%, compared to control, indicating that TTA is the most potent fatty acid. Indeed, at 50 nM, TTA reduced the growth by 36% whereas EPA was without any effect.

The incorporation of thymidine in the MCF-7 cells is shown in table 2. Compared to palmitic acid (control) this incorporation was reduced by 32% and 40% with EPA and

Table 1. Effect of EPA and TTA on cell growth (% of control) of human colon cancer cells (monolayer culture).

Cell line



50 nM


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